Severe depression with psychosis — ECT course; remission. Psychopharmacology: antipsychotics (typical — haloperidol — EPS; atypical — risperidone, olanzapine — metabolic; clozapine — resistant — agranulocytosis — WBC: side — EPS — dystonia, parkinsonism, akathisia — trihexyphenidyl; NMS — emergency), antidepressants (SSRIs — fluoxetine — first — 4–6 weeks; SNRIs — venlafaxine; TCAs — amitriptyline — overdose danger; MAOIs — diet; serotonin syndrome — hyperthermia — stop), mood stabilizers (lithium — 0.6–1.2 — thyroid/kidney; valproate — teratogenic; lamotrigine — rash), anxiolytics (benzodiazepines — short — dependence), ECT (severe depression, catatonia, psychotic — safe — brief anesthesia). Drugs need time — SSRIs take weeks.