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Urticaria, drug reactions — SJS, TEN

Dermatology, Venereology and Leprosy · MBBS

Study notes

Widespread blisters after drug — TEN; stop drug; burn unit care. Drug reactions: SJS (<10%) / TEN (>30%) — drug — anticonvulsants, allopurinol: painful — Nikolsky — mucosae: stop drug — burn unit — fluids, wound care; IVIG/cyclosporine): morbilliform (commonest — ampicillin: stop), urticaria (wheals — <24h — antihistamines — cetirizine; chronic — >6w — workup; angioedema — airway), anaphylaxis (adrenaline IM — 0.5mg — airway), erythema multiforme (target lesions — HSV — acyclovir). The drug + blister is SJS/TEN — stop the drug.

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