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Clinical biochemistry: liver function tests, renal function tests

Biochemistry · MBBS

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A jaundiced patient's labs: bilirubin high, ALT 1200, ALP normal, albumin normal. This is hepatocellular injury — ALT 1200 (massive liver cell damage, e.g. viral hepatitis or paracetamol poisoning) with normal ALP (no bile obstruction) and normal albumin/PT (synthesis still intact — acute, not chronic). The pattern discriminates: ALT-dominant = liver cells dying; ALP-dominant = bile blocked; low albumin/prolonged PT = chronic failure. LFTs are a pattern language — each enzyme a sentence about what's breaking.

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