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Generalized gingival enlargement with leukaemic infiltration is the first sign of leukaemia. Why does the dentist matter here? The mouth is examined routinely - bleeding, enlarged gums in a fatigued patient triggers the blood-test referral that diagnoses leukaemia early. Students learn the sentinel role: dentists see mouths more often than physicians see throats - oral signs (ulcers, bleeding, pigmentation, enlargement) are systemic disease's early posters.