Carbohydrate metabolism: glycogen metabolism, HMP shunt, diabetes biochemistry
Biochemistry · MBBS
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Study notes
A boy develops jaundice and dark urine after taking an antimalarial. This is G6PD deficiency — the X-linked enzyme defect leaves red cells unable to make NADPH via the HMP shunt, so oxidant drugs (primaquine, sulfa) or fava beans overwhelm glutathione defenses — hemoglobin denatures (Heinz bodies), membranes rupture, hemolysis. It is among the commonest enzyme defects worldwide — the HMP shunt's clinical face, and why drug histories matter in hemolysis.
Related topics
- Biomolecules: carbohydrates — structure and classification
- Biomolecules: lipids — structure, classification, lipoproteins
- Biomolecules: proteins — structure, classification, amino acids
- Biomolecules: nucleotides, nucleic acids, DNA structure
- Enzymes: kinetics, inhibition, regulation, clinical enzymology
- Bioenergetics: electron transport chain, oxidative phosphorylation