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Endocrinology: adrenal disorders, pituitary disorders, calcium disorders

General Medicine · MBBS

Study notes

Bronze skin, low BP, salt craving — Addison's; hydrocortisone replaces what the gland can't make. Primary adrenal insufficiency (autoimmune/TB — hyperpigmentation — ACTH excess, hypotension, hyponatremia, hyperkalemia: low cortisol, high ACTH): hydrocortisone + fludrocortisone lifelong; crisis (infection/surgery — fluids + IV hydrocortisone — emergency; stress-dose steroids). Cushing's (cortisol excess — moon face, striae, weight gain: dexamethasone suppression test; pituitary — Cushing's disease — surgery). Acromegaly (GH — large hands/jaw, IGF-1 high — transsphenoidal surgery). DI (polyuria — central: desmopressin; nephrogenic: thiazide). Calcium — hyper (PTH — stones, bones, groans — fluids + bisphosphonates) vs hypo (tetany — Chvostek's/Trousseau's — calcium + vitamin D). The bronze skin is ACTH — pigmentation points to the pituitary.

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