Muscle relaxants and reversal agents
Anesthesiology · MBBS
Study notes
Can't ventilate after suxamethonium — prolonged apnea; pseudocholinesterase deficiency; ventilate. Muscle relaxants: depolarizing (suxamethonium — rapid — 60s — intubation: side — hyperkalemia — burns; prolonged — pseudocholinesterase — ventilate; malignant hyperthermia — dantrolene), non-depolarizing (vecuronium, rocuronium — rapid; atracurium — organ-independent — Laudanosine; cisatracurium: reversal — needed), reversal (neostigmine + glycopyrrolate — bradycardia cover; sugammadex — rocuronium — encapsulates — fast; TOF — ≥0.9 — extubate). The prolonged apnea is pseudocholinesterase — ventilate till recovery.
Related topics
- Preoperative assessment and perioperative care
- General anesthesia: stages, inhalational and IV agents
- Regional anesthesia: spinal, epidural, nerve blocks
- Local anesthetics: pharmacology and toxicity
- Airway management: intubation, LMA, difficult airway
- Monitoring: pulse oximetry, capnography, hemodynamic monitoring